Semaglutide is a human-based glucagon-like peptide-1 receptor agonist prescribed as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) that is considered outside a healthy range.
GLP-1 is an important, gut-derived, regulator that is released after the oral ingestion of carbohydrates or fats. GLP-1 enhances insulin secretion and synthesis, suppresses glucagon secretion (glucagon increases sugar production), slows gastric emptying, and reduces appetite and food intake.
GLP-1 interacts with the parts of the brain that suppress your appetite and signal you to feel full. When used in conjunction with diet and exercise, it can cause significant weight loss. It can improve or lower the risk of diabetes and heart disease in people who are obese or overweight.
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